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Found 130 Enz. Inhib. hit(s) with Target = 'Cytochrome b-245 heavy chain'
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359525(CHEMBL1927146)
Affinity DataKi:  365nMAssay Description:Antagonist activity at human NOX2 in human polymorphonuclear cell membrane assessed as inhibition of ROS production after 20 mins by cell-free amplex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359522(CHEMBL1927160)
Affinity DataKi:  433nMAssay Description:Antagonist activity at human NOX2 in human polymorphonuclear cell membrane assessed as inhibition of ROS production after 20 mins by cell-free amplex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359520(CHEMBL1927158)
Affinity DataKi:  510nMAssay Description:Antagonist activity at human NOX2 in human polymorphonuclear cell membrane assessed as inhibition of ROS production after 20 mins by cell-free amplex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359527(CHEMBL1927148)
Affinity DataKi:  645nMAssay Description:Antagonist activity at human NOX2 in human polymorphonuclear cell membrane assessed as inhibition of ROS production after 20 mins by cell-free amplex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359533(CHEMBL1927154)
Affinity DataKi:  780nMAssay Description:Antagonist activity at human NOX2 in human polymorphonuclear cell membrane assessed as inhibition of ROS production after 20 mins by cell-free amplex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359521(CHEMBL1927159)
Affinity DataKi:  820nMAssay Description:Antagonist activity at human NOX2 in human polymorphonuclear cell membrane assessed as inhibition of ROS production after 20 mins by cell-free amplex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359534(CHEMBL1927155)
Affinity DataKi:  1.02E+3nMAssay Description:Antagonist activity at human NOX2 in human polymorphonuclear cell membrane assessed as inhibition of ROS production after 20 mins by cell-free amplex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359519(CHEMBL1927157)
Affinity DataKi:  1.14E+3nMAssay Description:Antagonist activity at human NOX2 in human polymorphonuclear cell membrane assessed as inhibition of ROS production after 20 mins by cell-free amplex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359529(CHEMBL1927150)
Affinity DataKi:  1.15E+3nMAssay Description:Antagonist activity at human NOX2 in human polymorphonuclear cell membrane assessed as inhibition of ROS production after 20 mins by cell-free amplex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359528(CHEMBL1927149)
Affinity DataKi:  1.16E+3nMAssay Description:Antagonist activity at human NOX2 in human polymorphonuclear cell membrane assessed as inhibition of ROS production after 20 mins by cell-free amplex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359532(CHEMBL1927153)
Affinity DataKi:  1.20E+3nMAssay Description:Antagonist activity at human NOX2 in human polymorphonuclear cell membrane assessed as inhibition of ROS production after 20 mins by cell-free amplex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359530(CHEMBL1927151)
Affinity DataKi:  1.26E+3nMAssay Description:Antagonist activity at human NOX2 in human polymorphonuclear cell membrane assessed as inhibition of ROS production after 20 mins by cell-free amplex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359524(CHEMBL1927145)
Affinity DataKi:  1.28E+3nMAssay Description:Antagonist activity at human NOX2 in human polymorphonuclear cell membrane assessed as inhibition of ROS production after 20 mins by cell-free amplex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359523(CHEMBL1927147)
Affinity DataKi:  1.34E+3nMAssay Description:Antagonist activity at human NOX2 in human polymorphonuclear cell membrane assessed as inhibition of ROS production after 20 mins by cell-free amplex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359518(CHEMBL1927156)
Affinity DataKi:  1.37E+3nMAssay Description:Antagonist activity at human NOX2 in human polymorphonuclear cell membrane assessed as inhibition of ROS production after 20 mins by cell-free amplex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50330722(2-(2-chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)...)
Affinity DataKi:  1.53E+3nMAssay Description:Inhibition of human NOX2 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359531(CHEMBL1927152)
Affinity DataKi:  1.76E+3nMAssay Description:Antagonist activity at human NOX2 in human polymorphonuclear cell membrane assessed as inhibition of ROS production after 20 mins by cell-free amplex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359526(CHEMBL1926690)
Affinity DataKi:  2.02E+3nMAssay Description:Antagonist activity at human NOX2 in human polymorphonuclear cell membrane assessed as inhibition of ROS production after 20 mins by cell-free amplex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50330688(4-methyl-2-phenyl-5-(pyridin-3-ylmethyl)-1H-pyrazo...)
Affinity DataKi:  4.72E+3nMAssay Description:Inhibition of human NOX2 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50497271(CHEMBL3347550)
Affinity DataIC50:  30nMAssay Description:Inhibition of full length human NOX2 transfected in COS 22 cells assessed as inhibition of lithium dodecyl sulphate-stimulated ROS generation preincu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50497270(CHEMBL3347551)
Affinity DataIC50:  30nMAssay Description:Inhibition of full length human NOX2 transfected in COS 22 cells assessed as inhibition of lithium dodecyl sulphate-stimulated ROS generation preincu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50218664(CHEMBL5275943)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against cell free dihydrofolate redutase (DHFR) from Mycobacterium lufuMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50612720(CHEMBL5279528)
Affinity DataIC50:  520nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50612719(CHEMBL5285816)
Affinity DataIC50:  910nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50612714(CHEMBL5279646)
Affinity DataIC50:  990nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM318936(US10173988, Compound A)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of human NOX2More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50612709(CHEMBL5282245)
Affinity DataIC50:  1.31E+3nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50612711(CHEMBL5278688)
Affinity DataIC50:  1.47E+3nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50612712(CHEMBL5269753)
Affinity DataIC50:  1.58E+3nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50612718(CHEMBL5269857)
Affinity DataIC50:  1.66E+3nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM318936(US10173988, Compound A)
Affinity DataIC50:  1.68E+3nMAssay Description:Cells: Human blood was purchased in buffy coat, prepared the same day for isolation of neutrophils, from Labjoy AB, Lund, Sweden. Blood components we...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50612701(CHEMBL5266372)
Affinity DataIC50:  1.76E+3nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50612704(CHEMBL5266063)
Affinity DataIC50:  1.90E+3nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50612710(CHEMBL5290483)
Affinity DataIC50:  1.95E+3nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50612703(CHEMBL5269456)
Affinity DataIC50:  1.96E+3nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50612706(CHEMBL5283659)
Affinity DataIC50:  2.40E+3nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50612707(CHEMBL5287636)
Affinity DataIC50:  2.72E+3nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50612715(CHEMBL5287582)
Affinity DataIC50:  2.79E+3nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50612705(CHEMBL5291222)
Affinity DataIC50:  2.82E+3nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50612713(CHEMBL5271584)
Affinity DataIC50:  2.82E+3nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50612716(CHEMBL5270712)
Affinity DataIC50:  2.96E+3nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50612722(CHEMBL5268914)
Affinity DataIC50:  3.39E+3nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50612700(CHEMBL5287478)
Affinity DataIC50:  3.58E+3nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50612717(CHEMBL5268551)
Affinity DataIC50:  3.73E+3nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50612721(CHEMBL5282886)
Affinity DataIC50:  5.00E+3nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM42323(1-(10H-phenothiazin-2-yl)ethanone | MLS000047624 |...)
Affinity DataIC50:  5.00E+3nMAssay Description:Data Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institut...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50612702(CHEMBL5290730)
Affinity DataIC50:  5.66E+3nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50612723(CHEMBL5286033)
Affinity DataIC50:  6.33E+3nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50497263(CHEMBL3347554)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of full length human NOX2 transfected in COS 22 cells assessed as inhibition of Phorbol 12-myristate 13-acetate-stimulated ROS generation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM65841(2-(trifluoromethyl)-10H-phenothiazine | SR-0100044...)
Affinity DataIC50:  9.00E+3nMAssay Description:Data Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institut...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
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